Control of ammonium ion level for efficient nanaomycin production.

نویسندگان

  • Y Tanaka
  • R Masuma
  • S Omura
چکیده

The addition of a small amount of NH4+ to a complex medium increased nanaomycin production by Streptomyces rosa subsp. notoensis OS-3966. The best NH4+ donor for nanaomycin production was NH4+-saturated natural zeolite, with which the maximum titer of nanaomycin E was 760 micrograms/ml, about four fold higher than the control titer. In contrast, lowering NH4+ levels by adding NH4+-trapping agents such as untreated natural zeolite reduced antibiotic production.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 37 11  شماره 

صفحات  -

تاریخ انتشار 1984